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SCR7
$280
Only 1000 item(s) left in stock.
Products Details
Product Description
– SCR7 is an unstable form that can be autocyclized into a stable form SCR7 pyrazine. SCR7 pyrazine is a DNA ligase IV inhibitor that blocks nonhomologous end-joining (NHEJ) in a ligase IV-dependent manner. SCR7 pyrazine is also a CRISPR/Cas9 enhancer which increases the efficiency of Cas9-mediated homology-directed repair (HDR). SCR7 pyrazine induces cell apoptosis and has anticancer activity[1][2].
Web ID
– HY-12742
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C18H14N4OS
Citations
– BMC Biotechnol. 2021 Jul 27;21(1):45.|EMBO Rep. 2019 Mar;20(3):e46821.|J Genet Genomics. 2021 Mar 30.|J Immunol. 2020 Apr 1;204(7):1904-1918.|J Immunother Cancer. 2022 Jan;10(1):e003809.|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.|Onco Targets Ther. 2018 Aug 17;11:4945-4953.|Sens Actuators B Chem. 19 February 2022, 131598.|Viruses. 2023 Nov 14, 15(11), 2256.|Int J Mol Sci. 2022, 23(14), 7518.
References
– [1]Srivastava M, et al. An inhibitor of nonhomologous end-joining abrogates double-strand break repair and impedes cancer progression. Cell. 2012 Dec 21;151(7):1474-87.|[2]Lin C, et al. Increasing the Efficiency of CRISPR/Cas9-mediated Precise Genome Editing of HSV-1 Virus in Human Cells. Sci Rep. 2016 Oct 7;6:34531.|[3]Supriya V Vartak, et al. Autocyclized and Oxidized Forms of SCR7 Induce Cancer Cell Death by Inhibiting Nonhomologous DNA End Joining in a Ligase IV Dependent Manner. FEBS J. 2018 Nov;285(21):3959-3976.
CAS Number
– 1533426-72-0
Molecular Weight
– 334.40
Compound Purity
– 98.22
SMILES
– O=C(C(/N=C/C1=CC=CC=C1)=C(/N=C/C2=CC=CC=C2)N3)NC3=S
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : ≥ 45 mg/mL
Target
– Apoptosis;CRISPR/Cas9;DNA/RNA Synthesis
Pathway
– Apoptosis;Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
