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Products Details
Product Description
– SCAL-266 is a potent mitochondrial complex I (CI) inhibitor with IC50 of 0.83 μM. SCAL-266 blocks mitochondrial function, inhibits OCR, induces ROS production, and reduces MMP. SCAL-266 displays a considerable antiproliferation effect against oxidative phosphorylation (OXPHOS)-dependent cancer cells[1].
Web ID
– HY-155555
Shipping
– Room temperature
Molecular Formula
– C27H28F3N5O2
References
– [1]Yang Zhou, et al. Synthesis and biological evaluation of novel pyrazole amides as potent mitochondrial complex I inhibitors. Eur J Med Chem. 2023 Oct 5;258:115576.
CAS Number
– 2798953-78-1
Molecular Weight
– 511.54
SMILES
– O=C(C1=NN(CC2=CC=CC(N3CCN(C(C4CC4)=O)CC3)=C2)C(C)=C1)NC5=CC=C(C(F)(F)F)C=C5
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Mitochondrial Metabolism
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
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