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SB290157 (trifluoroacetate)
$55 – $590
Products Details
Product Description
– SB290157 trifluoroacetate is a potent and selective C3a receptor antagonist with an IC50 of 200 nM.
Web ID
– HY-101502A
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture)
Shipping
– Blue Ice
Applications
– COVID-19-immunoregulation
Molecular Formula
– C24H29F3N4O6
Citations
– Animals (Basel). 2023 Feb 24.|Brain Sci. 2023, 13(2), 262.|Cell Death Dis. 2021 Mar 26;12(4):327.|Free Radic Biol Med. 2023 Jan 4;S0891-5849(23)00003-5.|Front Cell Dev Biol. 02 June 2021.|Immunobiology. 2023 Jan 18;228(2):152337.|Int Immunopharmacol. 2020 Oct;87:106814.|J Am Soc Nephrol. 2022 Jul 1;ASN.2021101384.|J Neuroinflammation. 2021 Feb 15;18(1):43.|Mat Sci Eng C-Mater. 2021, 111932.|Neurosci Lett. 2023 Feb 6;796:137049.|Research Square Preprint. 2020 Sep.|Toxicol Lett. 2023 Apr 19;S0378-4274(23)00168-6.|Cell Death Dis. 2020 May 15;11(5):377.
References
– [1]Ames RS, et al. Identification of a selective nonpeptide antagonist of the anaphylatoxin C3areceptor that demonstrates antiinflammatory activity in animal models. J Immunol. 2001 May 15;166(10):6341-8.|[2]Hutamekalin P, et al. Effect of the C3a-receptor antagonist SB 290157 on anti-OVA polyclonalantibody-induced arthritis. J Pharmacol Sci. 2010;112(1):56-63.
CAS Number
– 1140525-25-2
Molecular Weight
– 526.51
Compound Purity
– 99.87
SMILES
– N=C(N)NCCC[C@@H](C(O)=O)NC(COCC(C1=CC=CC=C1)C2=CC=CC=C2)=O.OC(C(F)(F)F)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– DMSO : 100 mg/mL (ultrasonic)|Ethanol : 100 mg/mL (ultrasonic)
Target
– Complement System
Pathway
– Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
