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SB-743921 (hydrochloride)
SKU
HY-12069-10 mg
Category Reference compound
Tags Cancer, Cell Cycle/DNA Damage;Cytoskeleton, Kinesin
$132 – $1,045
Products Details
Product Description
– SB-743921 hydrochloride is a potent inhibitor of the mitotic kinesin KSP (Eg5), with a Ki of 0.1 nM.
Web ID
– HY-12069
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C31H34Cl2N2O3
References
– [1]Jeffrey R. Jackson, et al. A second generation KSP inhibitor, SB-743921, is a highly potent and active therapeutic in preclinical models of cancer. First AACR International Conference on Molecular Diagnostics in Cancer Therapeutic Development, Sep 12-15, 2006.|[2]Yin Y, et al. Kinesin spindle protein inhibitor SB743921 induces mitotic arrest and apoptosis and overcomes imatinib resistance of chronic myeloid leukemia cells. Leuk Lymphoma. 2015 Jun;56(6):1813-20.|[3]Good JA, et al. Optimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models. J Med Chem. 2013 Mar 14;56(5):1878-93.
CAS Number
– 940929-33-9
Molecular Weight
– 553.52
Compound Purity
– 99.87
SMILES
– ClC1=CC2=C(C(C(CC3=CC=CC=C3)=C([C@@H](C(C)C)N(C(C4=CC=C(C=C4)C)=O)CCCN)O2)=O)C=C1.Cl
Clinical Information
– Phase 2
Research Area
– Cancer
Solubility
– DMSO : ≥ 100 mg/mL|H2O : 10 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Kinesin
Isoform
– Kinesin-5/Eg5/KSP
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Reference compound
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