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Products Details
Product Description
– SB-332235 is a potent, orally active nonpeptide CXCR2 antagonist, with an IC50 of 7.7 nM. SB-332235 displays 285-fold selectivity for CXCR2 over CXCR1. SB-332235 inhibits acute and chronic models of arthritis in the rabbit. SB-332235 inhibits viability of AML cells[1][2].
Web ID
– HY-16981
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C13H10Cl3N3O4S
References
– [1]Podolin PL, et al. A potent and selective nonpeptide antagonist of CXCR2 inhibits acute and chronic models of arthritis in the rabbit. J Immunol. 2002;169(11):6435-6444.|[2]Schinke C, et al. IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells [published correction appears in Blood. 2015 Jul 16;126(3):425. Barreryo, Laura [corrected to Barreyro, Laura]]. Blood. 2015;125(20):3144-3152.
CAS Number
– 276702-15-9
Molecular Weight
– 410.66
SMILES
– O=S(C1=C(Cl)C=CC(NC(NC2=CC=CC(Cl)=C2Cl)=O)=C1O)(N)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– CXCR
Pathway
– GPCR/G Protein;Immunology/Inflammation
Product type
– Reference compound
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