Download Files:
SB-209670
$571
Only 1000 item(s) left in stock.
Products Details
Product Description
– SB-209670 is an extremely potent and highly specific non-peptide, subnanomolar endothelin (ET) receptor antagonist. SB 209670 selectively inhibits binding of 125I-labeled ET-1 to cloned human ET receptor subtypes ETA and ETB (Ki=0.2 and 18 nM, respectively). SB 209670 produces a dose-dependent reduction in blood pressure in hypertensive rats, protects from ischemia-induced neuronal degeneration in a gerbil stroke model, and attenuates neointima formation following rat carotid artery balloon angioplasty[1].
Web ID
– HY-19210
Shipping
– Room temperature
Molecular Formula
– C29H28O9
References
– [1]E H Ohlstein, et al. SB 209670, a rationally designed potent nonpeptide endothelin receptor antagonist. Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):8052-6.
CAS Number
– 157659-79-5
Molecular Weight
– 520.53
SMILES
– O=C([C@@H]1[C@@H](C2=CC=C(OCO3)C3=C2)C4=C(C=C(OCCC)C=C4)[C@H]1C5=CC=C(OC)C=C5OCC(O)=O)O
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Endothelin Receptor
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
