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SB 204990

$115$1,240

Products Details

Product Description

– SB 204990 is a potent and specific inhibitor of ATP citrate lyase (ACLY) enzyme.

Web ID

– HY-16450

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Applications

– Metabolism-sugar/lipid metabolism

Molecular Formula

– C18H22Cl2O5

References

– [1]Shares BH, et al. Active mitochondria support osteogenic differentiation by stimulating β-catenin acetylation. J Biol Chem. 2018 Oct 12;293(41):16019-16027.|[2]Pearce NJ, et al. The role of ATP citrate-lyase in the metabolic regulation of plasma lipids. Hypolipidaemic effects of SB-204990, a lactone prodrug of the potent ATP citrate-lyase inhibitor SB-201076. Biochem J. 1998 Aug 15;334 ( Pt 1):113-9.

CAS Number

– 154566-12-8

Molecular Weight

– 389.27

Compound Purity

– 99.63

SMILES

– O=C(O)C[C@]1(O)C(O[C@H](CCCCCCC2=CC=C(Cl)C=C2Cl)C1)=O

Clinical Information

– No Development Reported

Research Area

– Metabolic Disease

Solubility

– DMSO : ≥ 100 mg/mL|H2O : 25 mg/mL (ultrasonic)

Target

– ATP Citrate Lyase

Pathway

– Metabolic Enzyme/Protease

Product type

– Reference compound

Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.

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