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Product Description
– Sanguinarine (Sanguinarin), a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.
Web ID
– HY-N0052
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C20H14NO4
Citations
– Comp Biochem Physiol C Toxicol Pharmacol. 28 October 2021, 109228.|Fishes. 2022, 7(5), 229.|Pestic Biochem Physiol. 10 October 2022, 105259.|Toxicol Lett. 2021 Jul 9;S0378-4274(21)00180-6.|Brain Behav Immun Health. 29 October 2022, 100546.|Phytother Res. 2023 Jul 11.|Research Square Print. 2022 Jun.
References
– [1]Wang Y, Noninvasive bioluminescence imaging of the dynamics of sanguinarine induced apoptosis via activation of reactive oxygen species. Oncotarget. 2016 Apr 19;7(16):22355-67.
CAS Number
– 2447-54-3
Molecular Weight
– 332.33
SMILES
– C[N+]1=CC2=C3C(OCO3)=CC=C2C(C=CC4=C5)=C1C4=CC6=C5OCO6
Clinical Information
– Launched
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Autophagy
Pathway
– Apoptosis;Autophagy
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
