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Salmeterol
$64 – $600
Products Details
Product Description
– Salmeterol (GR33343X) is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively[1].
Web ID
– HY-14302
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Molecular Formula
– C25H37NO4
Citations
– Cell Rep. 2019 Dec 3;29(10):2929-2935.e4|Drug Test Anal. 2020 Aug 27.|J Pharmaceut Biomed. 2020, 113870.|Nat Commun. 2020 Sep 25;11(1):4857.|Neurobiol Dis. 2020 Jul;140:104874.
References
– [1]Malcolm Johnson. Effects of beta2-agonists on resident and infiltrating inflammatory cells. J Allergy Clin Immunol. 2002 Dec;110(6 Suppl):S282-90.|[2]Zhiyuan Wang, et al. Efficacy of salmeterol and formoterol combination treatment in mice with chronic obstructive pulmonary disease. Exp Ther Med. 2018 Feb;15(2):1538-1545.|[3]Panayiotis A Procopiou, et al. The discovery of long-acting saligenin β₂ adrenergic receptor agonists incorporating a urea group. Bioorg Med Chem. 2011 Oct 15;19(20):6026-32.
CAS Number
– 89365-50-4
Molecular Weight
– 415.57
Compound Purity
– 99.91
SMILES
– OC1=CC=C(C(O)CNCCCCCCOCCCCC2=CC=CC=C2)C=C1CO
Clinical Information
– Launched
Research Area
– Endocrinology; Inflammation/Immunology
Solubility
– DMSO : ≥ 100 mg/mL
Target
– Adrenergic Receptor
Isoform
– β adrenergic receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
