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SAG (dihydrochloride)
$75 – $490
Products Details
Product Description
– SAG dihydrochloride is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG dihydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo[1][2][3].
Web ID
– HY-12848C
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C28H30Cl3N3OS
Citations
– UNIVERSIDAD DE CONCEPCIÓN. 2023 Apr.|Biochem Pharmacol. 2021 May 6;190:114593.|Cell Rep. 2020 Apr.|Cell Res. 2022 Mar;32(3):288-301.|Development. 2018 Sep 20;145(18). pii: dev164830.|Glia. 2021 Mar 11.|iScience. 2022 Dec 26;26(1):105898.|J Cell Mol Med. 2022 Jun;26(11):3213-3222.|J Pharm Biomed Anal. 2017 Aug 5;142:201-209.|Mol Brain. 2021 Jul 19;14(1):116.|Molecules. 2017 Dec 31;23(1). pii: E85.|Research Square Preprint. 2021 Sep.|Rheinische Friedrich-Wilhelms-Universität Bonn. Mathematisch-Naturwissenschaftlichen Fakultät. 2021 May 21.|Sci Adv. 2023 Jun 16;9(24):eadf6927.|Toxins. 2021 Aug 22;13(8):585.|Cancer Sci. 2021 Oct;112(10):4176-4186.|Drug Dev Res. 2019 Nov;80(7):992-999.
References
– [1]Chen JK, et al. Small molecule modulation of Smoothened activity. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14071-6.|[2]Stanton BZ, et al. A small molecule that binds Hedgehog and blocks its signaling in human cells. Nat Chem Biol. 2009 Mar;5(3):154-6.|[3]Lee S, et al. Combining Smoothened Agonist (SAG) and NEL-like protein-1 (NELL-1) Enhances Bone Healing. Plast Reconstr Surg. 2017 Feb 13.|[4]Fish EW, et al. Preaxial polydactyly following early gestational exposure to the smoothened agonist, SAG, in C57BL/6J mice. Birth Defects Res A Clin Mol Teratol. 2016 Nov 1.|[5]Guerrini G, et, al. Inhibition of smoothened in breast cancer cells reduces CAXII expression and cell migration. J Cell Physiol. 2018 Dec; 233(12): 9799-9811.
CAS Number
– 2702366-44-5
Molecular Weight
– 562.98
Compound Purity
– 99.56
SMILES
– O=C(C1=C(Cl)C2=CC=CC=C2S1)N([C@H]3CC[C@H](NC)CC3)CC4=CC=CC(C5=CC=NC=C5)=C4.[H]Cl.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 33.33 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)
Target
– Smo
Pathway
– Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
