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Products Details
Product Description
– Sacibertinib is a tyrosine kinase (Trk) inhibitor with EC50 value of 110 nM and 244 nM for EGFR-TK phosphorylation and HER2, respectively. Antineoplastic activity[1].
Web ID
– HY-147303
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C32H31ClN6O4
References
– [1]Hesheng Zhang, et al. Cyanoquinoline derivatives. CA2802130A1 (Example 138)|[2]International Nonproprietary Names for Pharmaceutical Substances (INN). WHO Drug Information, Vol. 36, No. 2, 2022.
CAS Number
– 1351941-69-9
Molecular Weight
– 599.08
SMILES
– CN(C)C/C=C/C(NC1=CC(C(NC2=CC(Cl)=C(C=C2)OCC3=CC=CC=N3)=C(C#N)C=N4)=C4C=C1O[C@H]5CCOC5)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– EGFR;Trk Receptor
Isoform
– EGFR/ErbB1/HER1;ErbB2/HER2
Pathway
– JAK/STAT Signaling;Neuronal Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
