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Products Details
Product Description
– Sabiporide hydrochloride is a NHE-1 inhibitor (Ki: 50 nM). Sabiporide hydrochloride has cardioprotective and neuroprotective effects. Sabiporide hydrochloride inhibits glutamate- or NMDA-induced neuronal cell death[1][2].
Web ID
– HY-122525A
Shipping
– Room temperature
Molecular Formula
– C18H20ClF3N6O2
References
– [1]Touret N, et al. Characterization of sabiporide, a new specific NHE-1 inhibitor exhibiting slow dissociation kinetics and cardioprotective effects. Eur J Pharmacol. 2003 Jan 17;459(2-3):151-8.|[2]Park HS, et al. Effects of sabiporide, a specific Na+/H+ exchanger inhibitor, on neuronal cell death and brain ischemia. Brain Res. 2005 Nov 2;1061(1):67-71.
CAS Number
– 324758-66-9
Molecular Weight
– 444.84
SMILES
– O=C(NC(N)=N)C1=CC=C(N2CCN(C(C3=CC=CN3)=O)CC2)C(C(F)(F)F)=C1.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Neurological Disease; Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Na+/H+ Exchanger (NHE)
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
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