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S1RA
$110 – $165
Products Details
Product Description
– S1RA (E-52862) is a highly active and selective sigma-1 receptor (σ1R) antagonist with a Ki of 17nM and a Ki of higher than 1000nM for σ2R.
Web ID
– HY-18099
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C20H23N3O2
References
– [1]Díaz JL, et al. Synthesis and biological evaluation of the 1-arylpyrazole class of σ(1) receptor antagonists: identification of 4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862). J Med Chem. 2012 Oct 11;55(19):8211-24.|[2]Romero L, et al. Pharmacological properties of S1RA, a new sigma-1 receptor antagonist that inhibits neuropathic pain and activity-induced spinal sensitization. Br J Pharmacol. 2012 Aug;166(8):2289-306.|[3]Vidal-Torres A, et al. Effects of the selective sigma-1 receptor antagonist S1RA on formalin-induced pain behavior and neurotransmitter release in the spinal cord in rats. J Neurochem. 2014 Jan 3.
CAS Number
– 878141-96-9
Molecular Weight
– 337.42
Compound Purity
– 98.0
SMILES
– CC1=CC(OCCN2CCOCC2)=NN1C3=CC(C=CC=C4)=C4C=C3
Clinical Information
– Phase 2
Research Area
– Neurological Disease
Solubility
– 1M HCl : 50 mg/mL (ultrasonic;adjust pH to 1 with HCl)|DMSO : 33.33 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Sigma Receptor
Isoform
– Sigma 1 Receptor
Pathway
– Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
