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Products Details
Product Description
– S1427 is a tranylcypromine-derived LSD1 inhibitor with the IC50 of 390 nM and Ki of 80 nM. S1427 exhibits desirable hERG channel inhibition and microsomal stability profiles. Inhibition of LSD1 partially reduces the proliferation of cancer cells[1].
Web ID
– HY-146380
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C25H29F3N4O2
References
– [1]Yasuko Koda, et al. Design and Synthesis of Tranylcypromine-Derived LSD1 Inhibitors with Improved hERG and Microsomal Stability Profiles. ACS Med Chem Lett. 2022 Apr 29;13(5):848-854.
CAS Number
– 2447061-40-5
Molecular Weight
– 474.52
SMILES
– O=C(N1CCC2(CC1)CCNC2)CN[C@H]3C[C@@H]3C4=C(C(F)=CC(F)=C4)OCC5=CC=CN=C5F
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Histone Demethylase
Isoform
– KDM1/LSD1
Pathway
– Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
