S130

$350$2,250

Products Details

Product Description

– S130 is a high affinity, selective inhibitor of ATG4B (a major cysteine protease) with an IC50 of 3.24 µM. S130 suppresses autophagy flux[1].

Web ID

– HY-112818

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Applications

– Cancer-Kinase/protease

Molecular Formula

– C24H25N3O2

References

– [1]Fu Y, et al. Discovery of a small molecule targeting autophagy via ATG4B inhibition and cell death of colorectal cancer cells in vitro and in vivo. Autophagy. 2018 Sep 20:1-17.

CAS Number

– 1160852-22-1

Molecular Weight

– 387.47

Compound Purity

– 99.43

SMILES

– O=C1C2=CC=CC=C2C3=C4C1=NC=C(C(NCCCN(CC)CC)=O)C4=CC=C3

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– DMSO : 125 mg/mL (ultrasonic)

Target

– Apoptosis;Atg4;Autophagy;Cathepsin

Pathway

– Apoptosis;Autophagy;Metabolic Enzyme/Protease

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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