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Product Description
– (S)-Monastrol ((+)-Monastrol) is an allosteric inhibitor of the mitotic kinesin Eg5 that exhibits an antiproliferative effect against several cancer cell lines. (S)-Monastrol arrests mammalian cells in mitosis with monopolar spindles[1][2].
Web ID
– HY-101071
Shipping
– Room temperature
Molecular Formula
– C14H16N2O3S
References
– [1]Marques LA, et al. Antiproliferative activity of monastrol in human adenocarcinoma (MCF-7) and non-tumor (HB4a) breast cells. Naunyn Schmiedebergs Arch Pharmacol. 2016 Dec;389(12):1279-1288.|[2]Mayer TU, et al. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science. 1999 Oct 29;286(5441):971-4.
CAS Number
– 254753-54-3
Molecular Weight
– 292.35
SMILES
– O=C(C1=C(C)NC(N[C@H]1C2=CC=CC(O)=C2)=S)OCC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Kinesin
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Reference compound
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