Products Details

Product Description

– S-2474 is an inhibitor of COX-2 and 5-lipoxygenase (5-LO), with IC50s of 11 nM and 27 μM for COX-2 and COX-1 in human intact cells, and used as a nonsteroidal anti-inflammatory agent.

Web ID

– HY-19212

Shipping

– Room temperature

Applications

– COVID-19-immunoregulation

Molecular Formula

– C20H31NO3S

References

– [1]Yagami T, et al. Effects of S-2474, a novel nonsteroidal anti-inflammatory drug, on amyloid beta protein-induced neuronal cell death. Br J Pharmacol. 2001 Oct;134(3):673-81.|[2]Yagami T, et al. S-2474, a novel nonsteroidal anti-inflammatory drug, rescues cortical neurons from human group IIA secretory phospholipase A(2)-induced apoptosis. Neuropharmacology. 2005 Aug;49(2):174-84. Epub 2005 Apr 1.

CAS Number

– 158089-95-3

Molecular Weight

– 365.53

SMILES

– OC1=C(C(C)(C)C)C=C(/C=C2CCN(CC)S2(=O)=O)C=C1C(C)(C)C

Clinical Information

– No Development Reported

Research Area

– Inflammation/Immunology

Solubility

– 10 mM in DMSO

Target

– COX;Lipoxygenase

Isoform

– 5-LOX;COX-1;COX-2

Pathway

– Immunology/Inflammation;Metabolic Enzyme/Protease

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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