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S-2474
SKU
HY-19212-Get quote
Category Reference compound
Tags COX;Lipoxygenase, Immunology/Inflammation;Metabolic Enzyme/Protease, Inflammation/Immunology
Products Details
Product Description
– S-2474 is an inhibitor of COX-2 and 5-lipoxygenase (5-LO), with IC50s of 11 nM and 27 μM for COX-2 and COX-1 in human intact cells, and used as a nonsteroidal anti-inflammatory agent.
Web ID
– HY-19212
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C20H31NO3S
References
– [1]Yagami T, et al. Effects of S-2474, a novel nonsteroidal anti-inflammatory drug, on amyloid beta protein-induced neuronal cell death. Br J Pharmacol. 2001 Oct;134(3):673-81.|[2]Yagami T, et al. S-2474, a novel nonsteroidal anti-inflammatory drug, rescues cortical neurons from human group IIA secretory phospholipase A(2)-induced apoptosis. Neuropharmacology. 2005 Aug;49(2):174-84. Epub 2005 Apr 1.
CAS Number
– 158089-95-3
Molecular Weight
– 365.53
SMILES
– OC1=C(C(C)(C)C)C=C(/C=C2CCN(CC)S2(=O)=O)C=C1C(C)(C)C
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– COX;Lipoxygenase
Isoform
– 5-LOX;COX-1;COX-2
Pathway
– Immunology/Inflammation;Metabolic Enzyme/Protease
Product type
– Reference compound
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