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Products Details
Product Description
– (R,R)-LRRK2-IN-7 is the isomer of LRRK2-IN-7 (HY-152107). LRRK2-IN-7 is a potent, selective, and CNS-penetrant LRRK2 kinase inhibitor with an IC50 of 0.9 nM. LRRK2-IN-7 shows >1000-fold selectivity over other kinases, ion channels, and CYP enzymes.
Web ID
– HY-152107A
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C24H26N6O
References
– [1]David A Candito, et al. Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1 H-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson’s Disease. J Med Chem. 2022 Dec 22;65(24):16801-16817.
CAS Number
– 2307277-92-3
Molecular Weight
– 414.50
SMILES
– CC(C)(O)[C@@H]1CCN(C1)C2=NC=NC(N3C4=CC([C@]5(CC56CC6)C#N)=CC=C4C=N3)=C2
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– LRRK2
Pathway
– Autophagy
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
