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Products Details
Product Description
– Rosuvastatin-d3 is a deuterium labeled Rosuvastatin. Rosuvastatin (ZD 4522) is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM[1]. Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC50 of 195 nM, delayed cardiac repolarization, and thereby prolonged action potential durations (APDs) and corrected QT interval (QTc) intervals[2].
Web ID
– HY-17504AS
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C22H25D3FN3O6S
References
– [1]Watanabe, M., et al., Synthesis and biological activity of methanesulfonamide pyrimidine- and N-methanesulfonyl pyrrole-substituted 3,5-dihydroxy-6-heptenoates, a novel series of HMG-CoA reductase inhibitors. Bioorg Med Chem, 1997. 5(2): p. 437-44.|[2]Carswell C.I., et al. Rosuvastatin. Drugs, 2002. 62(14): p. 2075-85; discussion 2086-7.
CAS Number
– 1133429-16-9
Molecular Weight
– 484.56
SMILES
– FC(C=C1)=CC=C1C2=NC(N(C([2H])([2H])[2H])S(=O)(C)=O)=NC(C(C)C)=C2/C=C/[C@@H](O)C[C@@H](O)CC(O)=O
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease; Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Autophagy;HMG-CoA Reductase (HMGCR);Isotope-Labeled Compounds;Potassium Channel
Pathway
– Autophagy;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Others
Product type
– Isotope-Labeled Compounds
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