Download Files:
Rosuvastatin (Calcium)
$25 – $158
Products Details
Product Description
– Rosuvastatin Calcium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC50 of 11 nM. Rosuvastatin Calcium potently blocks hERG current with an IC50 of 195 nM[2]. Rosuvastatin Calcium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Calcium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels[1][2][3].
Web ID
– HY-17504
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C22H27Ca0.5FN3O6S
Citations
– Acta Pharmacol Sin. 2023 Jan 31.|Front Bioeng Biotechnol. 2022 Mar 17;10:826093.|Front Cell Dev Biol. 2022 Mar 3;10:806081.|Eur J Pharmacol. 2023 Jul 13;955:175911.|Exp Ther Med. August 17, 2021.|Front Cell Dev Biol. 2021 May 6;9:651579.|Front Oncol. 10 May 2021.|Front Oncol. 2021 May 10;11:595285.|J Inflamm Res. 2021,14: 1537-1549.
References
– [1]Watanabe, M., et al., Synthesis and biological activity of methanesulfonamide pyrimidine- and N-methanesulfonyl pyrrole-substituted 3,5-dihydroxy-6-heptenoates, a novel series of HMG-CoA reductase inhibitors. Bioorg Med Chem, 1997. 5(2): p. 437-44.|[2]Plante I, et al. Rosuvastatin blocks hERG current and prolongs cardiac repolarization. J Pharm Sci. 2012 Feb;101(2):868-78.|[3]Feng PF, et al. Intracellular Mechanism of Rosuvastatin-Induced Decrease in Mature hERG Protein Expression on Membrane. Mol Pharm. 2019 Apr 1;16(4):1477-1488.|[4]Carswell C.I., et al. Rosuvastatin. Drugs, 2002. 62(14): p. 2075-85; discussion 2086-7.
CAS Number
– 147098-20-2
Molecular Weight
– 500.57
Compound Purity
– 99.94
SMILES
– O=C([O-])C[C@H](O)C[C@H](O)/C=C/C1=C(C(C)C)N=C(N(C)S(=O)(C)=O)N=C1C2=CC=C(F)C=C2.[0.5Ca2+]
Clinical Information
– Launched
Research Area
– Metabolic Disease; Cardiovascular Disease; Cancer
Solubility
– DMSO : 25 mg/mL (ultrasonic)|H2O : 1 mg/mL (ultrasonic)
Target
– Autophagy;Bacterial;HMG-CoA Reductase (HMGCR);Potassium Channel
Pathway
– Anti-infection;Autophagy;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
