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Product Description
– Rosuvastatin (ZD 4522) is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM. Rosuvastatin potently blocks hERG current with an IC50 of 195 nM, delayed cardiac repolarization, and thereby prolonged action potential durations (APDs) and corrected QT interval (QTc) intervals. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels[1][2][3].
Web ID
– HY-17504A
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C22H28FN3O6S
Citations
– Eur J Pharmacol. 2023 Jul 13;955:175911.|Exp Ther Med. August 17, 2021.|Front Cell Dev Biol. 2021 May 6;9:651579.|Front Oncol. 10 May 2021.|Front Oncol. 2021 May 10;11:595285.|J Inflamm Res. 2021,14: 1537-1549.|Acta Pharmacol Sin. 2023 Jan 31.|Front Bioeng Biotechnol. 2022 Mar 17;10:826093.|Front Cell Dev Biol. 2022 Mar 3;10:806081.
References
– [1]Watanabe, M., et al., Synthesis and biological activity of methanesulfonamide pyrimidine- and N-methanesulfonyl pyrrole-substituted 3,5-dihydroxy-6-heptenoates, a novel series of HMG-CoA reductase inhibitors. Bioorg Med Chem, 1997. 5(2): p. 437-44.|[2]Plante I, et al. Rosuvastatin blocks hERG current and prolongs cardiac repolarization. J Pharm Sci. 2012 Feb;101(2):868-78.|[3]Feng PF, et al. Intracellular Mechanism of Rosuvastatin-Induced Decrease in Mature hERG Protein Expression on Membrane. Mol Pharm. 2019 Apr 1;16(4):1477-1488.|[4]Carswell C.I., et al. Rosuvastatin. Drugs, 2002. 62(14): p. 2075-85; discussion 2086-7.
CAS Number
– 287714-41-4
Molecular Weight
– 481.54
SMILES
– O=C(O)C[C@H](O)C[C@H](O)/C=C/C1=C(C(C)C)N=C(N(C)S(=O)(C)=O)N=C1C2=CC=C(F)C=C2
Clinical Information
– Launched
Research Area
– Metabolic Disease; Cardiovascular Disease; Cancer
Solubility
– 10 mM in DMSO
Target
– Autophagy;Bacterial;HMG-CoA Reductase (HMGCR);Potassium Channel
Pathway
– Anti-infection;Autophagy;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease
Product type
– Reference compound
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