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Products Details
Product Description
– PNT100 is a 24-base, chemically unmodified DNA oligonucleotide sequence that is complementary to the regulatory region upstream of the BCL-2 gene. Exposure of tumor cells to PNT100 results in suppression of proliferation and cell death.
Web ID
– HY-153494
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C227H291N88O141P23
References
– [1]Rodrigueza WV, Woolliscroft MJ, Ebrahim AS, et al. Development and antitumor activity of a BCL-2 targeted single-stranded DNA oligonucleotide. Cancer Chemother Pharmacol. 2014;74(1):151-166.|[2]Westin J, Maris MB, Jacobson CA, et al. Safety and Efficacy of a DNA Oligonucleotide Therapy in Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma. Clin Lymphoma Myeloma Leuk. 2022;22(1):52-59.
CAS Number
– 871597-03-4
Molecular Weight
– 7220.63
SMILES
– [Rosomidnar]
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in H2O
Target
– Bcl-2 Family
Pathway
– Apoptosis
Product type
– Oligonucleotides
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
