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Ropivacaine (hydrochloride)
$32 – $79
Products Details
Product Description
– Ropivacaine hydrochloride is a potent sodium channel blocker and blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese[1][2]. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell’s membrane[3]. Ropivacaine is widely used for neuropathic pain management in vivo[1].
Web ID
– HY-B0563B
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C17H27ClN2O
Citations
– Eur Spine J. 2022 Sep 24.|Stem Cell Res Ther. 2021 Feb 4;12(1):107.|J Toxicol Sci. 2023;48(3):139-148.
References
– [1]Li TF, et al. Epidural sustained release ropivacaine prolongs anti-allodynia and anti-hyperalgesia in developing and established neuropathic pain. PLoS One. 2015 Jan 24;10(1):e0117321.|[2]Dene Simpson, et al. Ropivacaine: a review of its use in regional anaesthesia and acute pain management. Drugs. 2005;65(18):2675-717.|[3]Hye Won Shin, et al. The inhibitory effects of bupivacaine, levobupivacaine, and ropivacaine on K2P (two-pore domain potassium) channel TREK-1. J Anesth. 2014 Feb;28(1):81-6.|[4]Milan Patel, et al. Ropivacaine Inhibits Pressure-Induced Lung Endothelial Hyperpermeability in Models of Acute Hypertension. Life Sci. 2019 Apr 1;222:22-28.
CAS Number
– 98717-15-8
Molecular Weight
– 310.86
Compound Purity
– 99.93
SMILES
– [H]Cl.O=C([C@H]1N(CCC)CCCC1)NC2=C(C)C=CC=C2C
Clinical Information
– Launched
Research Area
– Neurological Disease; Cardiovascular Disease; Cancer
Solubility
– DMSO : 10 mg/mL (ultrasonic)|H2O : 10 mg/mL (ultrasonic)
Target
– Potassium Channel;Sodium Channel
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
