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Product Description
– Rolapitant hydrochloride hydrate (SCH619734 hydrochloride hydrate) is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a Ki of 0.66 nM. Rolapitant hydrochloride hydrate does not interact with CYP3A4. Rolapitant hydrochloride hydrate shows potent anti-emetic activity in a ferret emesis model[1][2].
Web ID
– HY-16436
Shipping
– Room temperature
Molecular Formula
– C25H29ClF6N2O3
References
– [1]Duffy RA, et al. Rolapitant (SCH 619734): a potent, selective and orally active neurokininNK1 receptor antagonist with centrally-mediated antiemetic effects inferrets. Pharmacol Biochem Behav. 2012 Jul;102(1):95-100.|[2]Rapoport B, et al. Study of rolapitant, a novel, long-acting, NK-1 receptor antagonist, for the prevention of chemotherapy-induced nausea and vomiting (CINV) due to highly emetogenic chemotherapy (HEC). Support Care Cancer. 2015 Nov;23(11):3281-8.
CAS Number
– 914462-92-3
Molecular Weight
– 554.95
SMILES
– O=C1N[C@]2(CN[C@@](C3=CC=CC=C3)(CO[C@@H](C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)C)CC2)CC1.[H]Cl.O
Clinical Information
– Phase 3
Research Area
– Cancer; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Neurokinin Receptor
Isoform
– NK1
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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