Rofecoxib-d5

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Products Details

Product Description

– Rofecoxib-d5 is the deuterium labeled Rofecoxib. Rofecoxib is a potent, specific and orally active COX-2 inhibitor, with IC50s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC50 > 50 μM in U937 cells and > 15 μM in Chinese hamster ovary cells)[1][2].

Web ID

– HY-17372S

Shipping

– Room temperature

Applications

– COVID-19-immunoregulation

Molecular Formula

– C17H9D5O4S

References

– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Rofecoxib, et al. Rofecoxib [Vioxx, MK-0966; 4-(4′-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles. J Pharmacol Exp Ther. 1999 Aug;290(2):551-60.|[3]Liu NN, et al. Rofecoxib inhibits retinal neovascularization via down regulation of cyclooxygenase-2 and vascular endothelial growth factor expression. Clin Exp Ophthalmol. 2015 Jul;43(5):458-65.|[4]Stoppoloni D, et al. Synergistic effect of gefitinib and rofecoxib in mesothelioma cells. Mol Cancer. 2010 Feb 2;9:27.

CAS Number

– 544684-93-7

Molecular Weight

– 319.39

SMILES

– O=C1C(C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])=C(C3=CC=C(C=C3)S(C)(=O)=O)CO1

Clinical Information

– No Development Reported

Research Area

– Inflammation/Immunology; Cancer

Solubility

– 10 mM in DMSO

Target

– COX;Isotope-Labeled Compounds

Pathway

– Immunology/Inflammation;Others

Product type

– Isotope-Labeled Compounds

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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