Download Files:
Rodatristat
$1,020 – $8,500
Products Details
Product Description
– Rodatristat (KAR5417) is a potent tryptophan hydroxylase 1 (TPH1) and TPH2 inhibitor with IC50s value of 33 nM and 7 nM, respectively, and shows robust reduction of intestinal serotonin (5-HT) levels in mice[1].
Web ID
– HY-120083
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C27H27ClF3N5O3
References
– [1]Goldberg DR, et al. Optimization of spirocyclic proline tryptophan hydroxylase-1 inhibitors. Bioorg Med Chem Lett. 2017 Feb 1;27(3):413-419.
CAS Number
– 1673568-73-4
Molecular Weight
– 561.98
Compound Purity
– 99.11
SMILES
– O=C([C@H]1NCC2(CCN(C3=NC(N)=NC(O[C@H](C4=CC=C(Cl)C=C4C5=CC=CC=C5)C(F)(F)F)=C3)CC2)C1)O
Clinical Information
– Phase 2
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– 5-HT Receptor;Tryptophan Hydroxylase
Isoform
– 5-HT Receptor
Pathway
– GPCR/G Protein;Metabolic Enzyme/Protease;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
