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Products Details
Product Description
– ROCK-IN-9 (Compound T345) is a ROCK inhibitor. ROCK-IN-9 shows cytotoxicity in HepG2 cell, with an IC50 of 40.8 μM. ROCK-IN-9 has good pharmacokinetic properties in mice, and shows high in vivo exposure and oral bioavailability at lower doses[1].
Web ID
– HY-156593
Shipping
– Room temperature
Molecular Formula
– C20H20FN5O2
References
– [1]Li, Jinping, et al. Rock inhibitor, preparation method therefor and use thereof. WO2021093795.
CAS Number
– 2643334-76-1
Molecular Weight
– 381.40
SMILES
– O=C(N1C2=C(CC1)C=C(C3=CNN=C3N)C(F)=C2)NCC4=CC(OC)=CC=C4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– ROCK
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton;Stem Cell/Wnt;TGF-beta/Smad
Product type
– Reference compound
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