Products Details

Product Description

– ROCK-IN-9 (Compound T345) is a ROCK inhibitor. ROCK-IN-9 shows cytotoxicity in HepG2 cell, with an IC50 of 40.8 μM. ROCK-IN-9 has good pharmacokinetic properties in mice, and shows high in vivo exposure and oral bioavailability at lower doses[1].

Web ID

– HY-156593

Shipping

– Room temperature

Molecular Formula

– C20H20FN5O2

References

– [1]Li, Jinping, et al. Rock inhibitor, preparation method therefor and use thereof. WO2021093795.

CAS Number

– 2643334-76-1

Molecular Weight

– 381.40

SMILES

– O=C(N1C2=C(CC1)C=C(C3=CNN=C3N)C(F)=C2)NCC4=CC(OC)=CC=C4

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– 10 mM in DMSO

Target

– ROCK

Pathway

– Cell Cycle/DNA Damage;Cytoskeleton;Stem Cell/Wnt;TGF-beta/Smad

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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