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Product Description
– Ro 67-4853 is a positive allosteric modulator (PAM) of mGluR1 (pEC50=7.16 for rmGlu1a receptor). Ro67-4853 exhibits activity at all group I mGlu receptors including hmGlu1, rmGlu1, and rmGlu5. Ro 67-4853 enhances the potency of L-Glu by interacting with the transmembrane domain (TMD) of the receptor. Ro 67-4853 potentiates sensory synaptic responses to repetitive vibrissa stimulation[1][2][3][4].
Web ID
– HY-107506
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C19H19NO4
References
– [1]Knoflach F, et al. Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site [published correction appears in Proc Natl Acad Sci U S A 2001 Dec 18;98(26):15393]. Proc Natl Acad Sci U S A. 2001;98(23):13402-13407. |[2]Jiang JY, et al. Extracellular calcium modulates actions of orthosteric and allosteric ligands on metabotropic glutamate receptor 1α. J Biol Chem. 2014;289(3):1649-1661.|[3]Salt TE, et al. Potentiation of sensory responses in ventrobasal thalamus in vivo via selective modulation of mGlu1 receptors with a positive allosteric modulator. Neuropharmacology. 2012;62(4):1695-1699. |[4]Sheffler DJ, et al. Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cells. Neuropharmacology. 2008;55(4):419-427.
CAS Number
– 302841-89-0
Molecular Weight
– 325.36
SMILES
– CCCCOC(NC(C1C2=CC=CC=C2OC3=CC=CC=C13)=O)=O
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– mGluR
Isoform
– mGluR1
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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