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Products Details
Product Description
– Ro 363, an effective inotropic stimulant, is a potent and highly selective β1-adrenoceptor agonist. RO 363 is a cardiovascular modulator that reduces diastolic blood pressure and pronounces increases in myocardial contractility[1][2][3].
Web ID
– HY-123268
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C19H25NO6
References
– [1]Maccarrone C, et al. Comparison of the Arrhythmogenic Actions of (-)-Isoprenaline, Dobutamine and the selective beta 1-adrenoceptor agonist, (+/-)-(1-[3′,4′-dihydroxyphenoxy] -2-hydroxy-[3″,4″-dimethoxy phenethylamino]-propane)-oxalate (Ro 363). Arzneimittelforschung. 1985;35(3):592-8.|[2]Iakovidis D, et al. In vitro activity of RO363, a beta1-adrenoceptor selective agonist. Br J Pharmacol. 1980 Apr;68(4):677-85.|[3]Einstein R, et al. Comparison of the cardiac effects of beta-adrenoreceptor agonists in anaesthetised and conscious dogs. J Auton Pharmacol. 1986 Mar;6(1):9-14.
CAS Number
– 74513-77-2
Molecular Weight
– 363.40
SMILES
– OC1=CC=C(C=C1O)OCC(CNCCC2=CC=C(C(OC)=C2)OC)O
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Adrenergic Receptor
Isoform
– β adrenergic receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
