Download Files:
RO-28-1675
$258 – $444
Products Details
Product Description
– RO-28-1675 is a potent allosteric glucokinase (GK) activator with an EC50 of 54 nM. RO-28-1675 can be used for the research of type 2 diabetes[1][2].
Web ID
– HY-10595
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C18H22N2O3S2
References
– [1]Joseph Grimsby, et al. Allosteric activators of glucokinase: potential role in diabetes therapy. Science. 2003 Jul 18;301(5631):370-3.|[2]Nancy-Ellen Haynes, et al. Discovery, structure-activity relationships, pharmacokinetics, and efficacy of glucokinase activator (2R)-3-cyclopentyl-2-(4-methanesulfonylphenyl)-N-thiazol-2-yl-propionamide (RO0281675). J Med Chem. 2010 May 13;53(9):3618-25.
CAS Number
– 300353-13-3
Molecular Weight
– 378.51
Compound Purity
– 99.95
SMILES
– O=C([C@@H](C1=CC=C(C=C1)S(=O)(C)=O)CC2CCCC2)NC3=NC=CS3
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– DMSO : 50 mg/mL (ultrasonic)
Target
– Glucokinase
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
