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Ro 25-6981 (Maleate)
$96 – $900
Products Details
Product Description
– Ro 25-6981 Maleate is a potent, selective and activity-dependent NR2B subunit specific NMDA receptor antagonist. Ro 25-6981 Maleat shows anticonvulsant and anti-parkinsonian activity. Ro 25-6981 Maleate has the potential for the research of parkinson’s disease (PD)[1][2][3].
Web ID
– HY-13993A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C26H33NO6
Citations
– Neurochem Int. 2020 Dec 16;104942.|Sci Rep. 2022 Oct 12;12(1):17114.|Cell Death Differ. 2023 May 4.|CNS Neurosci Ther. 2023 Jan 24.|Exp Brain Res. 2023 Oct 16.|Neuropharmacology. 2022 Jan 10;108947.
References
– [1]Löschmann PA, et al. Antiparkinsonian activity of Ro 25-6981, a NR2B subunit specific NMDA receptor antagonist, in animal models of Parkinson’s disease. Exp Neurol. 2004 May;187(1):86-93.|[2]Szczurowska E,et al. Different action of a specific NR2B/NMDA antagonist Ro 25-6981 on cortical evoked potentials and epileptic afterdischarges in immature rats. Brain Res Bull. 2015 Feb;111:1-8.|[3]Jiang M, et al. Antinociception and prevention of hyperalgesia by intrathecal administration of Ro 25-6981, a highly selective antagonist of the 2B subunit of N-methyl-D-aspartate receptor. Pharmacol Biochem Behav. 2013 Nov;112:56-63.
CAS Number
– 1312991-76-6
Molecular Weight
– 455.54
Compound Purity
– 98.22
SMILES
– OC1=CC=C([C@H](O)[C@@H](C)CN2CCC(CC3=CC=CC=C3)CC2)C=C1.O=C(O)/C=CC(O)=O
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : 100 mg/mL (ultrasonic)|H2O : 8.33 mg/mL (ultrasonic;warming;heat to 45°C)
Target
– iGluR
Isoform
– NMDA Receptor
Pathway
– Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
