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Products Details
Product Description
– RNA polymerase II-IN-1 (compound 19iv) is a amatoxin, inhibiting RNA polymerase II (Pol II) with an IC50 value of 36.66 nM. RNA polymerase II-IN-1 has higher cytotoxicity against cancer cells and less toxic in normal cells than α-Amanitin[1].
Web ID
– HY-147916
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C38H53N11O12S
References
– [1]Todorovic M, et al. Rationally Designed Amanitins Achieve Enhanced Cytotoxicity. J Med Chem. 2022 Jun 13.
CAS Number
– 2891451-07-1
Molecular Weight
– 887.96
SMILES
– O=C([C@@H](NC(CNC1=O)=O)[C@H](CC)C)NNC(N[C@@H]2C(N[C@H](C(N3C[C@@H](C[C@H]3C(N[C@H](C(N[C@@H]1CC4=C(SC2)NC5=C4C=CC=C5)=O)[C@H]([C@H](CO)O)C)=O)O)=O)CC(N)=O)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– DNA/RNA Synthesis
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
