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Products Details
Product Description
– RMS3, a tetrandrine analogue, is a potent P-glycoprotein (P-gp) inhibitor. RMS3 has markedly antiproliferative and cytotoxic effects on cancer cells. RMS3 causes PARP cleavage, a marker for cells undergoing apoptosis. RMS3 has strong anticancer property[1].
Web ID
– HY-146096
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C38H39F3N2O6
References
– [1]RamonaSchütz, et al. Synthesis, biological evaluation and toxicity of novel tetrandrine analogues. Eur J Med Chem. 2020 Dec 1;207:112810.
CAS Number
– 2497686-66-3
Molecular Weight
– 676.72
SMILES
– COC1=C2C3=C(C=C1OC)CCN(C)[C@@]3([H])CC4=CC=C(OC(F)(F)F)C(OC5=CC=C(C[C@]6([H])C7=CC(O2)=C(C=C7CCN6C)OC)C=C5)=C4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;P-glycoprotein
Pathway
– Apoptosis;Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
