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Products Details
Product Description
– RMS-07 is a covalent Monopolar Spindle Kinase 1 (MPS1/TTK) inhibitor, with an apparent IC50 of 13.1 nM. RMS-07 targets a poorly conserved cysteine in the kinase’s hinge region[1].
Web ID
– HY-144308
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C35H40N8O2
References
– [1]Ricardo A M Serafim, et al. Development of the First Covalent Monopolar Spindle Kinase 1 (MPS1/TTK) Inhibitor. J Med Chem. 2022 Feb 24;65(4):3173-3192.
CAS Number
– 2645409-78-3
Molecular Weight
– 604.74
SMILES
– O=C(C1=C2CCC3=CN=C(NC4=CC=C(N5CCN(C)CC5)C=C4NC(C=C)=O)N=C3N2C=C1)NC6=C(CC)C=CC=C6CC
Clinical Information
– No Development Reported
Research Area
– Others
Solubility
– 10 mM in DMSO
Target
– Mps1
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
