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Products Details
Product Description
– RIPK2-IN-1 (compound 18f) is a potent RIPK2 inhibitor with an IC50 of 51 nM. RIPK2-IN-1 inhibits ALK2 with an IC50 of 5 nM. RIPK2-IN-1 has an IC50 of 390 nM on RIPK2/NOD2 in cell assay[1].
Web ID
– HY-146694
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C23H27N5O3S
References
– [1]Chalada Suebsuwong, et al. Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold. Eur J Med Chem. 2020 Aug 15;200:112417.
CAS Number
– 2245820-70-4
Molecular Weight
– 453.56
SMILES
– COC1=CC(C2=C(N=CC(C3=CC=C(C=C3)N4CCNCC4)=C2)N)=CC(NS(C)(=O)=O)=C1
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Anaplastic lymphoma kinase (ALK);RIP kinase
Isoform
– RIPK2
Pathway
– Apoptosis;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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