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Products Details
Product Description
– RIPK2/3-IN-1 is a potent dual RIPK2/3 kinases inhibitor with IC50 values of 3 nM and 117 nM, respectively. RIPK2/3-IN-1 is against RIPK2 with IC50 value 14 nM in 14-TriLAN-Gly/NOD1 THP-1 cell-based NF-κB reporter assay[1].
Web ID
– HY-155151
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C24H16N4O2S2
References
– [1]Mbilo Misehe, et al. Exploring positions 6 and 7 of a quinazoline-based scaffold leads to changes in selectivity and potency towards RIPK2/3 kinases .Eur J Med Chem. 2023 Nov 15;260:115717.
Molecular Weight
– 456.54
SMILES
– OCC1=CC=C(O1)C2=CC3=C(C=C2C4=CC=CS4)C(NC5=CC(N=CS6)=C6C=C5)=NC=N3
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– RIP kinase
Pathway
– Apoptosis
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
