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Products Details
Product Description
– RIPK1-IN-12 is a potent RIPK1 inhibitor. RIPK1-IN-12 inhibits necroptosis in both human and mouse cells, with EC50 values of 1.6 and 2.9 nM, respectively[1].
Web ID
– HY-144277
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C24H26N4O3S
References
– [1]Li Z, et al. Design, synthesis, and evaluation of potent RIPK1 inhibitors with in vivo anti-inflammatory activity. Eur J Med Chem. 2022, 228:114036.
CAS Number
– 2173556-92-6
Molecular Weight
– 450.55
SMILES
– O=C(OC1CCCCC1)NC2=CC(C3=CC=C4N=C(NC(C5CC5)=O)SC4=C3)=CN=C2C
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Necroptosis;RIP kinase
Isoform
– RIPK1
Pathway
– Apoptosis
Product type
– Peptides
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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