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Rimonabant (Hydrochloride)
$49 – $396
Products Details
Product Description
– Rimonabant Hydrochloride (SR 141716A Hydrochloride) is a highly potent and selective central cannabinoid receptor (CB1) antagonist with an Ki of 1.8 nM. Rimonabant Hydrochloride (SR 141716A Hydrochloride) also inhibits Mycobacterial membrane protein Large 3 (MMPL3).
Web ID
– HY-14137
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C22H22Cl4N4O
Citations
– Cancers (Basel). 2021 Jan 18;13(2):330.|Neuroscience. 2019 Feb 19. pii: S0306-4522(19)30117-4. |Autophagy. 2021 Nov;17(11):3592-3606.|Cell. 2019 Jan 24;176(3):636-648.e13. |Structure. 2022 Aug 7;S0969-2126(22)00278-7.
References
– [1]Erdozain, A. M. et al. The inverse agonist effect of rimonabant on G protein activation is not mediated by the cannabinoid CB1 receptor: Evidence from postmortem human brain Biochemical Pharmacology (2012), 83(2), 260-268.|[2]Zhang B, et al. Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target. Cell. 2019 Jan 24;176(3):636-648.e13.|[3]Seely KA, et al. AM-251 and rimonabant act as direct antagonists at mu-opioid receptors: Implications for opioid/cannabinoid interaction studies. Neuropharmacology. 2012 Oct;63(5):905-15.
CAS Number
– 158681-13-1
Molecular Weight
– 500.25
Compound Purity
– 99.95
SMILES
– ClC1=CC=C(C2=C(C)C(C(NN3CCCCC3)=O)=NN2C4=CC=C(Cl)C=C4Cl)C=C1.Cl
Clinical Information
– Launched
Research Area
– Cancer; Infection; Metabolic Disease
Solubility
– DMSO : 33.33 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Bacterial;Cannabinoid Receptor
Isoform
– CB1
Pathway
– Anti-infection;GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
