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Products Details
Product Description
– Rimonabant-d10 (hydrochloride) is the deuterium labeled Rimonabant hydrochloride. Rimonabant hydrochloride (SR 141716A hydrochloride) is a highly potent and selective central cannabinoid receptor (CB1) antagonist with an Ki of 1.8 nM. Rimonabant hHydrochloride (SR 141716A Hydrochloride) also inhibits Mycobacterial membrane protein Large 3 (MMPL3)[1][2].
Web ID
– HY-14137S
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C22H12D10Cl4N4O
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Seely KA, et al. AM-251 and rimonabant act as direct antagonists at mu-opioid receptors: Implications for opioid/cannabinoid interaction studies. Neuropharmacology. 2012 Oct;63(5):905-15.|[3]Zhang B, et al. Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target. Cell. 2019 Jan 24;176(3):636-648.e13.|[4]Erdozain, A. M. et al. The inverse agonist effect of rimonabant on G protein activation is not mediated by the cannabinoid CB1 receptor: Evidence from postmortem human brain Biochemical Pharmacology (2012), 83(2), 260-268.
CAS Number
– 1044909-61-6
Molecular Weight
– 510.31
SMILES
– CC1=C(N(N=C1C(NN2C(C(C(C(C2([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])=O)C3=C(Cl)C=C(Cl)C=C3)C4=CC=C(Cl)C=C4.Cl
Clinical Information
– No Development Reported
Research Area
– Cancer; Infection; Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– Bacterial;Cannabinoid Receptor;Isotope-Labeled Compounds
Pathway
– Anti-infection;GPCR/G Protein;Neuronal Signaling;Others
Product type
– Isotope-Labeled Compounds
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