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Rhoifolin
$23 – $150
Products Details
Product Description
– Rhoifolin is a flavone glycoside can be isolated from Rhus succedanea. Rhoifolin has anti-diabetic effect acting through enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and glucose transporter 4 (GLUT 4) translocation. Rhoifolin has an anti-inflammatory action via multi-level regulation of inflammatory mediators. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways. Rhoifolin also has cytotoxic activity against different cancer cell lines[1][2][3].
Web ID
– HY-N0755
Storage Temperature
– 4°C (Powder, protect from light, stored under nitrogen)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C27H30O14
References
– [1]Rao YK, et al. Insulin-Mimetic Action of Rhoifolin and Cosmosiin Isolated from <i>Citrus grandis</i> (L.) Osbeck Leaves: Enhanced Adiponectin Secretion and Insulin Receptor Phosphorylation in 3T3-L1 Cells. Evid Based Complement Alternat Med. 2011;2011:624375.|[2]Liao S, et al. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways. J Cell Physiol. 2019 Aug;234(10):17600-17611.|[3]Omama E. El-Shawi, et al. Protective Effect of Rhoifolin on Gamma Irradiation Induced Cardiac Dysfunctions in Albino Mice. Feb 15, 2014. |[4]Eldahshan. O. A, et al. Rhoifolin; A Potent Antiproliferative Effect on Cancer Cell Lines. Journal of Pharmaceutical Research International, 2012, 3(1), pp. 46-53.
CAS Number
– 17306-46-6
Molecular Weight
– 578.52
Compound Purity
– 99.09
SMILES
– O=C(C=C(C1=CC=C(O)C=C1)OC2=CC(O[C@H](O[C@H](CO)[C@@H](O)[C@@H]3O)[C@@H]3O[C@@](O[C@@H](C)[C@H](O)[C@H]4O)([H])[C@@H]4O)=C5)C2=C5O
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease; Endocrinology; Cancer
Solubility
– DMSO : 62.5 mg/mL (ultrasonic)
Target
– Autophagy;GLUT;Insulin Receptor;NF-κB;p38 MAPK
Isoform
– GLUT4;NF-κB
Pathway
– Autophagy;MAPK/ERK Pathway;Membrane Transporter/Ion Channel;NF-κB;Protein Tyrosine Kinase/RTK
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
