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Products Details
Product Description
– RhlR antagonist 1 is a potent RhlR antagonist with an IC50 of 26 μM. RhlR antagonist 1 displays selective RhlR antagonism over LasR and PqsR, strong inhibition of biofilm formation in static and dynamic settings, and reduces production of virulence factors such as rhamnolipid and pyocyanin in P. aeruginosa. RhlR antagonist 1 can be utilized for developing QS-modulating molecules in the control of P. aeruginosa infections[1]. RhlR antagonist 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Web ID
– HY-131337
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C12H10F2O
References
– [1]Nam S, et al. Discovery and characterization of pure RhlR antagonists against Pseudomonas aeruginosa infections [published online ahead of print, 2020 Jul 22]. J Med Chem. 2020;10.1021/acs.jmedchem.0c00630.
CAS Number
– 2614320-29-3
Molecular Weight
– 208.20
SMILES
– CCCC(C#CC1=CC=C(F)C(F)=C1)=O
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Bacterial
Pathway
– Anti-infection
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
