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RF9
$108 – $242
Products Details
Product Description
– RF9 is a potent and selective Neuropeptide FF receptor antagonist, with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively[1][2].
Web ID
– HY-107382
Storage Temperature
– -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Shipping
– Blue Ice
Applications
– COVID-19-immunoregulation
Molecular Formula
– C26H38N6O3
References
– [1]Simonin F, et al. RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia. Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):466-71.|[2]Ting Zhang, et al. Discovery of Two Novel Branched Peptidomimetics Containing endomorphin-2 and RF9 Pharmacophores: Synthesis and Neuropharmacological Evaluation. Bioorg Med Chem. 2019 Feb 15;27(4):630-643.
CAS Number
– 876310-60-0
Molecular Weight
– 482.62
Compound Purity
– 98.24
SMILES
– NC([C@H](CC1=CC=CC=C1)NC([C@H](CCCNC(N)=N)NC(C23C[C@H](C4)C[C@H](C[C@H]4C3)C2)=O)=O)=O
Clinical Information
– No Development Reported
Research Area
– Endocrinology; Neurological Disease; Cardiovascular Disease
Solubility
– DMSO : 125 mg/mL (ultrasonic)|H2O : 16.67 mg/mL (ultrasonic)
Target
– Neuropeptide Y Receptor
Isoform
– NPY Y1 receptor;NPY Y2 receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
