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Retinoic acid-d6
SKU
HY-14649S3-Get quote
Category Isotope-Labeled Compounds
Tags Autophagy;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor, Autophagy;Endogenous Metabolite;PPAR;RAR/RXR, Cancer
Products Details
Product Description
– Retinoic acid-d6 is the deuterium labeled Retinoic acid[1]. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha[2][3][4][5][6][7].
Web ID
– HY-14649S3
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C20H22D6O2
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Wu L, et al. Retinoid X Receptor Agonists Upregulate Genes Responsible for the Biosynthesis of All-Trans-Retinoic Acid in Human Epidermis. PLoS One. 2016 Apr 14;11(4):e0153556.;
CAS Number
– 2483831-72-5
Molecular Weight
– 306.47
SMILES
– OC(/C=C(C([2H])([2H])[2H])/C=C/C=C(C([2H])([2H])[2H])/C=C/C1=C(C)CCCC1(C)C)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Autophagy;Endogenous Metabolite;PPAR;RAR/RXR
Pathway
– Autophagy;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Product type
– Isotope-Labeled Compounds
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