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Products Details
Product Description
– Reticulol (K 251-1) is an inhibitor of cyclic adenosine 3′, 5′-monophosphate phosphodiesterase. Reticulol shows antitumor activity independent with cell cycle arrest or apoptosis. Reticulol inhibits cell growth of murine melanoma cells and human lung tumor cells. Reticulol protects its lung metastasis via the bloodstream by inhibiting the growth of B16F10 melanoma[1][2].
Web ID
– HY-120241
Shipping
– Room temperature
Molecular Formula
– C11H10O5
References
– [1]Furutani Y, et al. Reticulol, an inhibitor of cyclic adenosine 3′, 5′-monophosphate phosphodiesterase. J Antibiot (Tokyo). 1975 Jul;28(7):558-60. |[2]Lim DS, et al. Antitumor efficacy of reticulol from Streptoverticillium against the lung metastasis model B16F10 melanoma. Lung metastasis inhibition by growth inhibition of melanoma. Chemotherapy. 2003 Jun;49(3):146-53. |[3]Furutani Y, et al. Reticulol, an inhibitor of cyclic adenosine 3′, 5′-monophosphate phosphodiesterase. J Antibiot (Tokyo). 1975 Jul;28(7):558-60.
CAS Number
– 26246-41-3
Molecular Weight
– 222.19
SMILES
– O=C1C2=C(O)C(OC)=C(O)C=C2C=C(C)O1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Phosphodiesterase (PDE)
Pathway
– Metabolic Enzyme/Protease
Product type
– Natural Products
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