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RET-IN-20
SKU
HY-151987-Get quote
Category Reference compound
Tags Apoptosis;Protein Tyrosine Kinase/RTK, Apoptosis;RET, Cancer
Products Details
Product Description
– RET-IN-20 is a potent RET inhibitor with an IC50 value of 13.7 nM. RET-IN-20 decreases the expression of p-Ret, p-Shc protein. RET-IN-20 induces apoptosis. RET-IN-20 shows antiproliferative and anti-tumor activity[1].
Web ID
– HY-151987
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C32H33FN6O4
References
– [1]Zhang Y, et al. 1-Methyl-3-((4-(quinolin-4-yloxy)phenyl)amino)-1H-pyrazole-4-carboxamide derivatives as new rearranged during Transfection (RET) kinase inhibitors capable of suppressing resistant mutants in solvent-front regions. Eur J Med Chem. 2022 Dec 15;244:114862.
Molecular Weight
– 584.64
SMILES
– COC1=C(C=C2C(N=CC=C2OC3=CC=C(C=C3F)NC4=NN(C=C4C(NC56CC7CC(C6)CC(C5)C7)=O)C)=C1)C(N)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;RET
Pathway
– Apoptosis;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.