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Products Details
Product Description
– RET-IN-14 (compound 49) is a potent RET inhibitor with IC50s of <0.51 nM, 9.3 nM, 1.3 nM, 9.2 nM, 15 nM for RET (WT), RET (G810R), RET (V804M), BTK and BTK (C481S), respectively. RET-IN-14 has the potential for tumors research[1]
Web ID
– HY-144170
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C24H23FN8O4
References
– [1]Jing Wang, et al. Compounds with macrocyclic structure and their uses. WO2021244609A1.
CAS Number
– 2755843-62-8
Molecular Weight
– 506.49
SMILES
– NC1=C(C2=CC=C(C=C2)NC(OC)=O)C3=NC4=C(C(NC[C@@H](OC5=NC=C(F)C=C5CN3)C)=O)C=NN14
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Btk;RET
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
