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Products Details
Product Description
– RET-IN-11 is a potent and selective RET inhibitor with IC50s of 6.20 nM, 18.68 nM for RET and RETV804M, respectively. RET-IN-11 shows anti-proliferation and migration activity in CCDC6-RET-driven LC-2/ad cells. RET-IN-11 induces cell apoptosis[1].
Web ID
– HY-144131
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C27H30FN9O
References
– [1]Zhang L, et al. Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose. J Med Chem. 2022 Jan 27;65(2):1536-1551.
CAS Number
– 2764891-88-3
Molecular Weight
– 515.59
SMILES
– O=C(NC1=CC=CC(F)=C1)CC2=CC=C(NC3=NC(N4CCN(C)CC4)=CC(NC5=CC(C)=NN5)=N3)C=C2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;RET
Pathway
– Apoptosis;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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