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Products Details
Product Description
– Resolvin E1-d4-1 is the deuterium labeled Resolvin E1. Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production[1][2].
Web ID
– HY-114041S1
Shipping
– Room temperature
Molecular Formula
– C20H26D4O5
References
– [1]Arita M, et al. Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7671-6.|[2]Schwab JM, et al. Resolvin E1 and protectin D1 activate inflammation-resolution programmes. Nature. 2007 Jun 14;447(7146):869-74.|[3]Hasturk H, et al. Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissuehomeostasis in vivo. J Immunol. 2007 Nov 15;179(10):7021-9.|[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
CAS Number
– 2714040-94-3
Molecular Weight
– 354.47
SMILES
– CC[C@H](O)/C=C/C([2H])=C([2H])C[C@@H](O)/C=C/C=C/C([2H])=C([2H])[C@@H](O)CCCC(O)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Endogenous Metabolite;Isotope-Labeled Compounds
Pathway
– Metabolic Enzyme/Protease;Others
Product type
– Isotope-Labeled Compounds
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