Resolvin D2-d5

$396

Only 1000 item(s) left in stock.

Products Details

Product Description

– Resolvin D2-d5 is the deuterium labeled Resolvin D2. Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of TRPV1 (IC50 = 0.1 nM) and TRPA1 (IC50 = 2 nM) in primary sensory neurons[1][2][3].

Web ID

– HY-121636S

Shipping

– Room temperature

Molecular Formula

– C22H27D5O5

References

– [1]Spite M, et al. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Nature. 2009 Oct 29;461(7268):1287-91.|[2]Park CK, et al. Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1.6. J Neurosci. 2011 Dec 14;31(50):18433-8.|[3]Siddiqui YD, et al. Resolvin D2 Induces Resolution of Periapical Inflammation and Promotes Healing of Periapical Lesions in Rat Periapical Periodontitis. Front Immunol. 2019 Feb 26;10:307.|[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

CAS Number

– 1881277-33-3

Molecular Weight

– 381.52

SMILES

– [2H]C(C([2H])([2H])[2H])(/C=CC[C@@H]([C@@H](/C=C/C=C/C=CC=C[C@H](C/C=CCCC(O)=O)O)O)O)[2H]

Clinical Information

– No Development Reported

Research Area

– Infection; Inflammation/Immunology; Neurological Disease

Solubility

– 10 mM in DMSO

Target

– TRP Channel

Pathway

– Membrane Transporter/Ion Channel;Neuronal Signaling

Product type

– Isotope-Labeled Compounds

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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