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rel-Paroxetine-d4 (hydrochloride)
$848
Only 1000 item(s) left in stock.
Products Details
Product Description
– rel-Paroxetine-d4 (hydrochloride) is an isotope-labeled Paroxetine hydrochloride (HY-B0492). Paroxetine hydrochloride is an orally active and selective serotonin-reuptake inhibitor, commonly prescribed as an GRK2 inhibitor with IC50 of 14 μM. Paroxetine hydrochloride can be used for the research of depressive disorder[1][2][3][4].
Web ID
– HY-151216S
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C19H17D4ClFNO3
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. |[2]Wang Q, et al. Paroxetine alleviates T lymphocyte activation and infiltration to joints of collagen-induced arthritis. Sci Rep. 2017 Mar 28;7:45364. |[3]Liu RP, et al. Paroxetine ameliorates lipopolysaccharide-induced microglia activation via differential regulation of MAPK signaling. J Neuroinflammation. 2014 Mar 12;11:47. |[4]Hwang S, et al. Inhibitory effect of the selective serotonin reuptake inhibitor paroxetine on human Kv1.3 channels. Eur J Pharmacol. 2021 Dec 5;912:174567.
CAS Number
– 1217683-35-6
Molecular Weight
– 369.85
SMILES
– FC(C([2H])=C1[2H])=C([2H])C([2H])=C1[C@H](CCNC2)[C@@H]2COC3=CC=C(OCO4)C4=C3.Cl
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Autophagy;Serotonin Transporter
Pathway
– Autophagy;Neuronal Signaling
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
